IFNλ Effector Reporter Cell
CBP74684
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| I. Background | |
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IFNλ（III型干扰素）是干扰素家族的一个独特成员，在结构上与IL-10相关，但功能上具有抗病毒活性。人类主要有IFNλ1（IL-29）、IFNλ2（IL-28A）和IFNλ3（IL-28B） 三种。与广泛作用于全身的I型干扰素不同，IFNλ的受体主要表达于上皮细胞，因此它被认为是黏膜表面（如呼吸道、肠道）的一道“前线”防御屏障，能在不引发全身性炎症的情况下局部控制病毒感染。 |
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| II. Description | |
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IFNλ Effector Reporter Cell 报告基因药靶模型很好的模拟了体内 IFNλ 的信号转导过程。 |
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| III. Introduction | |
| Expressed gene: | IFNλ |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM + 10% FBS +2 μg/ml Puromycin + 5 μg/ml Blasticidin + 200 μg/ml Hygromycin B |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
IV. Representative Data Figure 1. Dose Response of Ligands in IFNλ Effector Reporter Cell( C26).  Figure 2. Inhibition of Human Recombinant IL29 Induced Reporter Activity by IL29 Neutralization Ab in IFNλ Effector Reporter Cell (C26).
 Figure 3. Inhibition of Human Recombinant IL28a Induced Reporter Activity by IL28a Neutralization Ab in IFNλ Effector Reporter Cell(C26).
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